Rooney Mara leads the picture as Emily Hawkins, who is reunited with her husband (Tatum), recently released from prison. But his return ups her anxiety, and when she turns to meds to try and regulate her feelings, things begin to spiral out of control. Penned by Scott Z. Burns ("Contagion"), this looks like a pretty ace little mindbender, with a first-rate supporting cast including Jude Law (as Emily's psychiatrist, who seems to have his own more personal interest in her), Catherine Zeta-Jones, Vinessa Shaw and more.
Oh yeah, that music in the first part of the trailer? That's "Physical Liaison" from Clint Mansell's score to "Last Night" (listen below), but it's actually Thomas Newman who will be tuning up the finished picture. "Side Effects" opens on February 8, 2013.