He'll join Matthew McConaughey and Jennifer Garner and in the film based on the true story of Ron Woodruff (McConaughey), who was diagnosed with AIDS in 1986 and was only given months to live. With nothing to lose, he began experimenting with underground, non-FDA-approved drugs and wound up living longer than expected. He began getting these drugs into the hands of other AIDS sufferers as well, but it wasn't long before the FDA tried to shut him down. Leto will replace the previoiusly cast Gael Garcia Bernal (boo!), playing the cross-dressing AIDS patient who Ron meets in the hospital.
Production on the movie begins next week in New Orleans, which is remarkable in itself given how long this movie has been kicking around. Jean-Marc Vallée ("Café de Flore," "The Young Victoria") will direct and we can only presume this will be an awards contender for next year. [Deadline]