The Hollywood Reporter has a list of the top grossing comedy films led by actresses and surprise your highest grossing female comedy actress in Meryl Streep. Her comedic films have earned $1.3 billion. They include Mamma Mia, The Devil Wears Prada, It's Complicated and Julie & Julia.
Number 2 - Sarah Jessica Parker - $916 million.
Number 3 - Katherine Heigl - $773 million.
Number 4- Cameron Diaz - $768 million.
Number 5 - Anne Hathaway - $727 million.
Wish some of these ladies recent films would have been watchable. But I am always hopeful for the future.
Who Are the Top Grossing Actresses in Comedy? (Hollywood Reporter)